Using the unique spectral signature of guano to identify unknown seabird colonies

Despite the threats faced by seabirds in both terrestrial and marine habitats, even basic knowledge of the locations of colonies, population sizes and trends is lacking for many remote areas of the world. Recent studies have shown that the guano of Adélie penguins can be identified from Landsat Enhanced Thematic Mapper (ETM) imagery and used to map colonies on coasts around continental Antarctica. Our study highlights a new technique based on the unique spectral signature of guano that can be used to discriminate seabird colonies from background geology and vegetation in a wider range of natural environments, including the vegetated and zoologically-diverse region of the Antarctic Peninsula; moreover, the method was effective for all densely colonial, surface-nesting seabirds. Using Landsat ETM imagery, we correctly identified all known seabird colonies of over 50 pairs in the area of Marguerite Bay. Almost all other areas with a similar spectral signature that were outside known breeding areas were single pixels that were readily distinguishable from genuine colonies. If these were excluded, only 4.1% of pixels appeared to represent unknown breeding or roosting sites, and warrant further investigation. The spatial extent of the guano provided a general guide to the number of individuals present, but further work would be required to determine the accuracy of this method for estimating population size. Spectral profiles of guano collected by satellite and hand-held spectrometers were compared with available data in spectral libraries and did not match with any known geological profile. There may also be potential for discriminating colonies of different species that differ in phenology and show seasonal changes in diet by the carefully-timed acquisition of suitable satellite imagery. We conclude that the remotely-sensed guano signature is a good indicator of the location of seabird breeding or roosting sites, with potentially wide application to other areas of the world

Oceanic and atmospheric forcing of Larsen C Ice-Shelf thinning

The catastrophic collapses of Larsen A and B ice shelves on the eastern Antarctic Peninsula have caused their tributary glaciers to accelerate, contributing to sea-level rise and freshening the Antarctic Bottom Water formed nearby. The surface of Larsen C Ice Shelf (LCIS), the largest ice shelf on the peninsula, is lowering. This could be caused by unbalanced ocean melting (ice loss) or enhanced firn melting and compaction (englacial air loss). Using a novel method to analyse eight radar surveys, this study derives separate estimates of ice and air thickness changes during a 15-year period. The uncertainties are considerable, but the primary estimate is that the surveyed lowering (0.066 ± 0.017 m yr−1) is caused by both ice loss (0.28 ± 0.18 m yr−1) and firn-air loss (0.037 ± 0.026 m yr−1). The ice loss is much larger than the air loss, but both contribute approximately equally to the lowering because the ice is floating. The ice loss could be explained by high basal melting and/or ice divergence, and the air loss by low surface accumulation or high surface melting and/or compaction. The primary estimate therefore requires that at least two forcings caused the surveyed lowering. Mechanisms are discussed by which LCIS stability could be compromised in the future. The most rapid pathways to collapse are offered by the ungrounding of LCIS from Bawden Ice Rise or ice-front retreat past a "compressive arch" in strain rates. Recent evidence suggests that either mechanism could pose an imminent risk

Covers of acts over monoids II

In 1981 Edgar Enochs conjectured that every module has a flat cover and finally proved this in 2001. Since then a great deal of effort has been spent on studying different types of covers, for example injective and torsion free covers. In 2008, Mahmoudi and Renshaw initiated the study of flat covers of acts over monoids but their definition of cover was slightly different from that of Enochs. Recently, Bailey and Renshaw produced some preliminary results on the `other' type of cover and it is this work that is extended in this paper. We consider free, divisible, torsion free and injective covers and demonstrate that in some cases the results are quite different from the module case

The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils

Staphylococcus aureus is a major human pathogen causing multiple pathologies, from cutaneous lesions to life-threatening sepsis. Although neutrophils contribute to immunity against S. aureus, multiple lines of evidence suggest that these phagocytes can provide an intracellular niche for staphylococcal dissemination. However, the mechanism of neutrophil subversion by intracellular S. aureus remains unknown. Targeting of intracellular pathogens by macroautophagy/autophagy is recognized as an important component of host innate immunity, but whether autophagy is beneficial or detrimental to S. aureus-infected hosts remains controversial. Here, using larval zebrafish, we showed that the autophagy marker Lc3 rapidly decorates S. aureus following engulfment by macrophages and neutrophils. Upon phagocytosis by neutrophils, Lc3-positive, non-acidified spacious phagosomes are formed. This response is dependent on phagocyte NADPH oxidase as both cyba/p22phox knockdown and diphenyleneiodonium (DPI) treatment inhibited Lc3 decoration of phagosomes. Importantly, NADPH oxidase inhibition diverted neutrophil S. aureus processing into tight acidified vesicles, which resulted in increased host resistance to the infection. Some intracellular bacteria within neutrophils were also tagged by Sqstm1/p62-GFP fusion protein and loss of Sqstm1 impaired host defense. Together, we have shown that intracellular handling of S. aureus by neutrophils is best explained by Lc3-associated phagocytosis (LAP), which appears to provide an intracellular niche for bacterial pathogenesis, while the selective autophagy receptor Sqstm1 is host-protective. The antagonistic roles of LAP and Sqstm1-mediated pathways in S. aureus-infected neutrophils may explain the conflicting reports relating to anti-staphylococcal autophagy and provide new insights for therapeutic strategies against antimicrobial-resistant Staphylococci

Optical investigation of the charge-density-wave phase transitions in NbSe3NbSe_{3}

We have measured the optical reflectivity $R(\omega)$ of the quasi one-dimensional conductor $NbSe_{3}$ from the far infrared up to the ultraviolet between 10 and 300 $K$ using light polarized along and normal to the chain axis. We find a depletion of the optical conductivity with decreasing temperature for both polarizations in the mid to far-infrared region. This leads to a redistribution of spectral weight from low to high energies due to partial gapping of the Fermi surface below the charge-density-wave transitions at 145 K and 59 K. We deduce the bulk magnitudes of the CDW gaps and discuss the scattering of ungapped free charge carriers and the role of fluctuations effects

Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift

In humans, low serum carnosinase (CN1) activity protects patients with type 2 diabetes from diabetic nephropathy. We now characterized the interaction of thiol-containing compounds with CN1 cysteine residue at position 102, which is important for CN1 activity. Reduced glutathione (GSH), N-acetylcysteine and cysteine (3.2 \uc2\ub1 0.4, 2.0 \uc2\ub1 0.3, 1.6 \uc2\ub1 0.2 \uc2\ub5mol/mg/h/mM; p <.05) lowered dose-dependently recombinant CN1 (rCN1) efficiency (5.2 \uc2\ub1 0.2 \uc2\ub5mol/mg/h/mM) and normalized increased CN1 activity renal tissue samples of diabetic mice. Inhibition was allosteric. Substitution of rCN1 cysteine residues at position 102 (Mut1C102S) and 229 (Mut2C229S) revealed that only cysteine-102 is influenced by cysteinylation. Molecular dynamic simulation confirmed a conformational rearrangement of negatively charged residues surrounding the zinc ions causing a partial shift of the carnosine ammonium head and resulting in a less effective pose of the substrate within the catalytic cavity and decreased activity. Cysteine-compounds influence the dynamic behaviour of CN1 and therefore present a promising option for the treatment of diabetes

Electromagnetic Response of Layered Superconductors with Broken Lattice Inversion Symmetry

We investigate the macroscopic effects of charge density waves (CDW) and superconductivity in layered superconducting systems with broken lattice inversion symmetry (allowing for piezoelectricity) such as two dimensional (2D) transition metal dichalcogenides (TMD). We work with the low temperature time dependent Ginzburg-Landau theory and study the coupling of lattice distortions and low energy CDW collective modes to the superconducting order parameter in the presence of electromagnetic fields. We show that superconductivity and piezoelectricity can coexist in these singular metals. Furthermore, our study indicates the nature of the quantum phase transition between a commensurate CDW phase and the stripe phase that has been observed as a function of applied pressure.Comment: 9 pages, 1 figure. Final version. Accepted in Phys.Rev.

Variation in the dispersions of powder liquid ratios in hand-mix glass ionomers

BACKGROUND: The Powder/Liquid Ratio (PLR) influence, and the literature regarding the handling and physical properties of Glass Ionomer restorative materials (GIC) were investigated. OBJECTIVE: The objective of the study was to compare the PLR variability and magnitude in hand-mix GICs, as dispensed for clinical use. From the recorded individual powder and liquid weights, additional comparisons could be made by pairing the various “extreme” outer observations in relation to the manufacturer’s PLR. STUDY DESIGN: The materials assessed were Ketac Universal Hand-mix (KUH), Riva Self Cure Hand-mix (RSCH) and Fuji IX GP Hand-mix (FIXH). Twenty scoops of powder were paired with twenty drops of liquid, as would be the case in the clinical scenario. Statistical analysis was completed with the Kruskal Wallis H test, Intraclass Correlation (ICC) and straight line regressions with One-way ANOVA and the post-hoc Tukey HSD Test (p<0.05 was considered significant). RESULTS: The powder and liquid observations indicate a lack of consistency in both the powder and liquid dispersions. The volume remained “one drop” but the weights were much lower than the manufacturer’s recommended drop weight for some observations, due to air in the liquid drop. The Kruskal-Wallis H test indicated significant differences (p=0.0001) between the three materials for the paired PLRs. The One-way ANOVA and post-hoc Tukey HSD Test were used to compare the recommended PLR to the results and the significant differences (p<0.01). CONCLUSION: The recommended manufacturers’ powder and liquid weights were KUH 0.150/0.05g; RSC 0.165/0.035; FIXH 0.18/0.05, respectively. KUH, FIXH and RSCH liquid had powder and liquid dispersions above the manufacturer’s recommendations. FIXH had the most paired PLR observations within the ±10% range followed by KUH. Extreme powder and liquid combinations could occur in the clinical scenario and these combinations were considered

X-Ray Scattering Measurements of the Transient Structure of a Driven Charge-Density-Wave

We report time-resolved x-ray scattering measurements of the transient structural response of the sliding {\bf Q}$_{1}$ charge-density-wave (CDW) in NbSe$_{3}$ to a reversal of the driving electric field. The observed time scale characterizing this response at 70K varies from $\sim$ 15 msec for driving fields near threshold to $\sim$ 2 msec for fields well above threshold. The position and time-dependent strain of the CDW is analyzed in terms of a phenomenological equation of motion for the phase of the CDW order parameter. The value of the damping constant, $\gamma = (3.2 \pm 0.7) \times 10^{-19}$ eV $\cdot$ seconds $\cdot$ \AA$^{-3}$, is in excellent agreement with the value determined from transport measurements. As the driving field approaches threshold from above, the line shape becomes bimodal, suggesting that the CDW does not depin throughout the entire sample at one well-defined voltage.Comment: revtex 3.0, 7 figure

Hard Scattering Factorization from Effective Field Theory

In this paper we show how gauge symmetries in an effective theory can be used to simplify proofs of factorization formulae in highly energetic hadronic processes. We use the soft-collinear effective theory, generalized to deal with back-to-back jets of collinear particles. Our proofs do not depend on the choice of a particular gauge, and the formalism is applicable to both exclusive and inclusive factorization. As examples we treat the pi-gamma form factor (gamma gamma* -> pi^0), light meson form factors (gamma* M -> M), as well as deep inelastic scattering (e- p -> e- X), Drell-Yan (p pbar -> X l+ l-), and deeply virtual Compton scattering (gamma* p -> gamma(*) p).Comment: 35 pages, 4 figures, typos corrected, journal versio